LRRC4C antibody (AA 561-640) (Biotin)

Catalog No. ABIN720298

Product Details anti-LRRC4C Antibody (Biotin)

Target: LRRC4C (Leucine Rich Repeat Containing 4C (LRRC4C))

Binding Specificity: AA 561-640

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC4C antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Netrin G1 ligand

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for LRRC4C

Target: LRRC4C (Leucine Rich Repeat Containing 4C (LRRC4C))

Alternative Name: Netrin G1 ligand (LRRC4C Products)

Synonyms: 6430556C10Rik antibody, NGL-1 antibody, mKIAA1580 antibody, RGD1311013 antibody, fd12d10 antibody, wu:fd12d10 antibody, zgc:110565 antibody, NGL1 antibody, leucine rich repeat containing 4C antibody, Lrrc4c antibody, lrrc4c antibody, LRRC4C antibody

Background:

Synonyms: Leucine rich repeat containing 4C, Leucine-rich repeat-containing protein 4C, LRC4C_HUMAN, Lrrc4C, Netrin-G1 ligand, NGL 1, NGL-1, NGL1.

Background: NGL-1 is a single pass type I membrane protein that acts as a cell adhesion molecule. It contains nine leucine-rich repeats (LRR) and one Ig-like C2-type domain. NGL-1 is predominantly expressed in the striatum and the cerebral cortex of both the embryonic and adult brain. NGL-1 specifically interacts with Netrin G1 (a molecule involved in axon guidance in the developing central nervous system) via its LRR region. NGL-1 plays a role in the regulation of neurite outgrowth of developing thalamic neurons. Soluble NGL-1 inhibits thalamic axon outgrowth while NGL-1 that is bound to the surface of developing thalamocortical axons stimulates growth. NGL-1 also interacts with Whirlin possibly stablizing interstereociliar links.

Gene ID: 22854

Pathways: Synaptic Membrane