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GATSL3 antibody

GATSL3 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7469300
  • Target See all GATSL3 products
    GATSL3 (GATS Protein-Like 3 (GATSL3))
    Reactivity
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 2
    Rabbit
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This GATSL3 antibody is un-conjugated
    Application
    Western Blotting (WB)
    Cross-Reactivity
    Human
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human GATSL3. The exact sequence is proprietary.
    Isotype
    IgG
  • Application Notes
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: MCF-7 , MDA-MB-231

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.9 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    GATSL3 (GATS Protein-Like 3 (GATSL3))
    Alternative Name
    GATSL3 (GATSL3 Products)
    Synonyms
    2410008K03Rik antibody, RGD1304774 antibody, cytosolic arginine sensor for mTORC1 subunit 1 antibody, GATS protein-like 3 antibody, CASTOR1 antibody, Gatsl3 antibody, Castor1 antibody
    Background

    Synonyms: cytosolic arginine sensor for mTORC1 subunit 1 , GATSL3

    Background: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

    Molecular Weight
    36 kDa
    Gene ID
    652968
    UniProt
    Q8WTX7
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