PMS2CL/PMS2 antibody (N-Term)
PMS2
Reactivity: Human
IP, WB
Host: Rabbit
Polyclonal
unconjugated
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- Target See all PMS2CL/PMS2 (PMS2) products
- PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))
- Binding Specificity
- N-Term
- Reactivity
- Human
-
Host
- Rabbit
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Clonality
- Polyclonal
-
Conjugate
- This PMS2CL/PMS2 antibody is un-conjugated
- Application
- Immunoprecipitation (IP), Western Blotting (WB)
- Cross-Reactivity
- Human
- Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the N-terminus region of human PMS2. The exact sequence is proprietary.
- Isotype
- IgG
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- Application Notes
- WB: 1:500-1:10000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: human PMS2-transfected 293T cells , A431 , HeLa , HepG2 Validation: Overexpression
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))
- Alternative Name
- PMS1 homolog 2, mismatch repair system component (PMS2 Products)
- Background
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Synonyms: PMS1 homolog 2, mismatch repair system component , HNPCC4 , MLH4 , PMS2CL , PMSL2
Background: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq]
- Molecular Weight
- 96 kDa
- Gene ID
- 5395
- UniProt
- P54278
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