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PMS2CL/PMS2 antibody (N-Term)

PMS2 Reactivity: Human IP, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7468755
  • Target See all PMS2CL/PMS2 (PMS2) products
    PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))
    Binding Specificity
    N-Term
    Reactivity
    Human
    Host
    • 1
    Rabbit
    Clonality
    • 1
    Polyclonal
    Conjugate
    • 1
    This PMS2CL/PMS2 antibody is un-conjugated
    Application
    Immunoprecipitation (IP), Western Blotting (WB)
    Cross-Reactivity
    Human
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the N-terminus region of human PMS2. The exact sequence is proprietary.
    Isotype
    IgG
  • Application Notes
    WB: 1:500-1:10000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: human PMS2-transfected 293T cells , A431 , HeLa , HepG2 Validation: Overexpression

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))
    Alternative Name
    PMS1 homolog 2, mismatch repair system component (PMS2 Products)
    Synonyms
    HNPCC4 antibody, PMS2CL antibody, PMSL2 antibody, PMS1 homolog 2, mismatch repair system component antibody, PMS2 antibody
    Background

    Synonyms: PMS1 homolog 2, mismatch repair system component , HNPCC4 , MLH4 , PMS2CL , PMSL2

    Background: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq]

    Molecular Weight
    96 kDa
    Gene ID
    5395
    UniProt
    P54278
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