ATR antibody (AA 710-1100)

Catalog No. ABIN7467985

Product Details anti-ATR Antibody

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Binding Specificity: AA 710-1100

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATR antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Functional Studies (Func)

Cross-Reactivity: Human, Mouse

Purification: Protein G purified

Immunogen: Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.

Clone: 2B5

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Raji , Raji nuclear extract Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for ATR

Target: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Alternative Name: ATR serine/threonine kinase (ATR Products)

Background:

Synonyms: ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1

Background: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

Molecular Weight: 301 kDa

Gene ID: 545

UniProt: Q13535

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus