TRIM72 antibody
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- Target See all TRIM72 Antibodies
- TRIM72 (Tripartite Motif Containing 72 (TRIM72))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRIM72 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse
- Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human TRIM72. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product TRIM72 Primary Antibody
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- Application Notes
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Validation: Orthogonal
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.42 mg/mL
- Buffer
- 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- TRIM72 (Tripartite Motif Containing 72 (TRIM72))
- Alternative Name
- tripartite motif containing 72 (TRIM72 Products)
- Synonyms
- Trim72 antibody, MG53 antibody, Mg53 antibody, BC067209 antibody, RGD1562778 antibody, tripartite motif containing 72 antibody, tripartite motif containing 72, E3 ubiquitin protein ligase L homeolog antibody, tripartite motif-containing 72 antibody, TRIM72 antibody, trim72.L antibody, Trim72 antibody
- Background
- Tripartite motif containing 72 , MG53,Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
- Molecular Weight
- 53 kDa
- Gene ID
- 493829
- UniProt
- Q6ZMU5
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