EP400 antibody
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- Target See all EP400 Antibodies
- EP400 (E1A Binding Protein P400 (EP400))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EP400 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Cross-Reactivity
- Human
- Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human p400. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product EP400 Primary Antibody
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- Application Notes
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: MCF-7
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.95 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- EP400 (E1A Binding Protein P400 (EP400))
- Alternative Name
- E1A binding protein p400 (EP400 Products)
- Synonyms
- CAGH32 antibody, P400 antibody, TNRC12 antibody, 1700020J09Rik antibody, AU023439 antibody, mDomino antibody, mKIAA1498 antibody, p400 antibody, E1A binding protein p400 antibody, EP400 N-terminal-like protein antibody, helicase domino antibody, E1a binding protein P400 antibody, EP400 antibody, Ep400 antibody, LOC738562 antibody, LOC5570719 antibody, CpipJ_CPIJ007689 antibody, CpipJ_CPIJ007688 antibody, CpipJ_CPIJ007686 antibody, CpipJ_CPIJ008061 antibody
- Background
- E1A binding protein p400 , CAGH32 , P400 , TNRC12,Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.
- Molecular Weight
- 343 kDa
- Gene ID
- 57634
- UniProt
- Q96L91
- Pathways
- Chromatin Binding
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