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EP400 antibody

EP400 Reactivity: Human WB, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7466625
  • Target See all EP400 Antibodies
    EP400 (E1A Binding Protein P400 (EP400))
    Reactivity
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 5
    • 4
    Rabbit
    Clonality
    • 7
    • 2
    Polyclonal
    Conjugate
    • 9
    This EP400 antibody is un-conjugated
    Application
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human p400. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product EP400 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: MCF-7

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.95 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    EP400 (E1A Binding Protein P400 (EP400))
    Alternative Name
    E1A binding protein p400 (EP400 Products)
    Synonyms
    CAGH32 antibody, P400 antibody, TNRC12 antibody, 1700020J09Rik antibody, AU023439 antibody, mDomino antibody, mKIAA1498 antibody, p400 antibody, E1A binding protein p400 antibody, EP400 N-terminal-like protein antibody, helicase domino antibody, E1a binding protein P400 antibody, EP400 antibody, Ep400 antibody, LOC738562 antibody, LOC5570719 antibody, CpipJ_CPIJ007689 antibody, CpipJ_CPIJ007688 antibody, CpipJ_CPIJ007686 antibody, CpipJ_CPIJ008061 antibody
    Background
    E1A binding protein p400 , CAGH32 , P400 , TNRC12,Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.
    Molecular Weight
    343 kDa
    Gene ID
    57634
    UniProt
    Q96L91
    Pathways
    Chromatin Binding
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