HLA-DQB1 antibody
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- Target See all HLA-DQB1 Antibodies
- HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HLA-DQB1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human
- Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human HLA-DQB1. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product HLA-DQB1 Primary Antibody
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- Application Notes
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: Jurkat
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.7 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))
- Alternative Name
- major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1 Products)
- Synonyms
- CELIAC1 antibody, HLA-DQB antibody, IDDM1 antibody, mhc-DRB antibody, DLA-DQB antibody, MAMU-DQB1 antibody, LOC100172120 antibody, DKFZp469C0237 antibody, major histocompatibility complex, class II, DQ beta 1 antibody, HLA-DQB1 antibody, PATR-DQB1 antibody, DLA-DQB1 antibody, MAMU-DQB1 antibody, LOC100172120 antibody
- Background
- Major histocompatibility complex, class II, DQ beta 1 , CELIAC1 , HLA-DQB , IDDM1,HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
- Molecular Weight
- 30 kDa
- Gene ID
- 3119
- UniProt
- P01920
- Pathways
- TCR Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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