TYK2 antibody (AA 401-500)

Catalog No. ABIN719591

Product Details anti-TYK2 Antibody

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Binding Specificity: AA 401-500

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TYK2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: TYK2 (TYK2 Products)

Synonyms: JTK1 antibody, tyrosine kinase 2 antibody, TYK2 antibody, Tyk2 antibody

Background:

Synonyms: JTK 1, JTK1, Non receptor tyrosine protein kinase 2, Non receptor tyrosine protein kinase TYK2, Non-receptor tyrosine-protein kinase TYK2, Protein Tyrosine Kinase 2, TYK 2, Tyk2, TYK2_HUMAN, Tyrosine kinase 2.

Background: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].

Gene ID: 7297

Pathways: JAK-STAT Signaling, Hepatitis C