PREX1 antibody

Catalog No. ABIN7464628

Product Details anti-PREX1 Antibody

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PREX1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PREX1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: human PREX1-transfected 293T cells (partial)

Validation: Overexpression

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for PREX1

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Alternative Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (PREX1 Products)

Synonyms: MGC68772 antibody, P-REX1 antibody, G630042G04 antibody, Setd6 antibody, RGD1306534 antibody, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog antibody, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 antibody, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 antibody, prex1.L antibody, PREX1 antibody, prex1 antibody, Prex1 antibody

Background: Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 , P-REX1,The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq]

Molecular Weight: 186 kDa

Gene ID: 57580

UniProt: Q8TCU6

Pathways: Regulation of Actin Filament Polymerization