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TET1 antibody

KO Validated TET1 Reactivity: Human WB, IF, IHC (p), ICC Host: Mouse Monoclonal GT1462 unconjugated
Catalog No. ABIN7464226
  • Target See all TET1 Antibodies
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Reactivity
    • 14
    • 12
    • 3
    Human
    Host
    • 14
    • 6
    • 1
    Mouse
    Clonality
    • 13
    • 8
    Monoclonal
    Conjugate
    • 17
    • 2
    • 1
    • 1
    This TET1 antibody is un-conjugated
    Application
    • 15
    • 9
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human, Mouse
    Purification
    Affinity purified by Protein G.
    Grade
    KO Validated
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human TET1. The exact sequence is proprietary.
    Clone
    GT1462
    Isotype
    IgG2b
    Top Product
    Discover our top product TET1 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: 293T , DDDDK-human TET1-transfected 293T cells , NT2D1 nuclear extract

    Validation: KO/KD, Orthogonal, Overexpression

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, No Preservative
    Preservative
    Without preservative
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Alternative Name
    tet methylcytosine dioxygenase 1 (TET1 Products)
    Synonyms
    CXXC6 antibody, LCX antibody, bA119F7.1 antibody, 2510010B09Rik antibody, AA517754 antibody, BB001228 antibody, Cxxc6 antibody, D10Ertd17e antibody, mKIAA1676 antibody, tet methylcytosine dioxygenase 1 antibody, solute carrier family 25 member 16 antibody, TET1 antibody, Tet1 antibody, SLC25A16 antibody
    Background
    Tet methylcytosine dioxygenase 1 , CXXC6 , LCX , bA119F7.1,Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
    Molecular Weight
    235 kDa
    Gene ID
    80312
    UniProt
    Q8NFU7
    Pathways
    Stem Cell Maintenance, Warburg Effect
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