SELPLG antibody
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- Target See all SELPLG Antibodies
- SELPLG (Selectin P Ligand (SELPLG))
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This SELPLG antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Blocking Reagent (BR)
- Purification
- Purified
- Clone
- 4RA10
- Isotype
- IgG1, kappa
- Top Product
- Discover our top product SELPLG Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Matching Isotype Control: Purified Rat IgG1, κ Isotype Control (ABIN7469819)
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS with 0.05 % Proclin300
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2~8°C. Do not freeze.
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- Target
- SELPLG (Selectin P Ligand (SELPLG))
- Alternative Name
- CD162 (SELPLG Products)
- Background
- P-selectin glycoprotein ligand 1,Selplg,PSGL-1,Selectin P ligand,CD162,The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.
- Gene ID
- 20345
- UniProt
- Q62170
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