Recombinant UBQLN4 antibody (AA 2-601)

Catalog No. ABIN7455161

Product Details anti-UBQLN4 Antibody

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Antibody Type: Recombinant Antibody

Binding Specificity: AA 2-601

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This UBQLN4 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-UBQLN4/CIP75/Ubiquilin 4 Recombinant Monoclonal Antibody [BLR145J]

Immunogen: residues 2-601 (full length)

Clone: BLR145J

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 20 μL/1 mg lysate

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Alternative Name: UBQLN4/CIP75/Ubiquilin 4 (UBQLN4 Products)

Synonyms: a1u antibody, cip75 antibody, ubin antibody, ubiquilin-4 antibody, A1U antibody, A1Up antibody, C1orf6 antibody, CIP75 antibody, UBIN antibody, A1u antibody, AI663987 antibody, RGD1308273 antibody, ubiquilin 4 L homeolog antibody, ubiquilin 4 antibody, ubqln4.L antibody, ubqln4 antibody, UBQLN4 antibody, Ubqln4 antibody

Background: Background: Ubiquilin-4 (UBQLN4) plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). It mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. UBQLN4 Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). It acts as an adapter protein that recruits UBQLN1 to the autophagy machinery and mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) [taken from NCBI Entrez Gene (Gene ID: 56893)].

Gene ID: 56893

NCBI Accession: NP_064516

UniProt: Q9NRR5