PALB2 antibody (AA 675-725)

Catalog No. ABIN7454733

Product Details anti-PALB2 Antibody

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Binding Specificity: AA 675-725

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PALB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-PALB2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 675 and 725

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PALB2

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Alternative Name: PALB2 (PALB2 Products)

Synonyms: PALB2 antibody, Fancn antibody, si:ch211-14k19.9 antibody, FANCN antibody, PNCA3 antibody, 4732427B05 antibody, BC066140 antibody, RGD1304759 antibody, partner and localizer of BRCA2 antibody, partner and localizer of BRCA2 L homeolog antibody, PALB2 antibody, palb2 antibody, palb2.L antibody, Palb2 antibody

Background: Background: PALB2 (partner and localizer of BRCA2) interacts with BRCA2 and promotes BRCA2 localization and stability. PALB2 is also known as FANCN. Bi-allelic mutations in PALB2 result in Fanconi anemia disorder and breast cancer susceptibility. At the cellular level, PALB2 is important to the DNA damage response and chromosome stability and is essential to BRCA2 function.

Gene ID: 79728

NCBI Accession: NP_078951

UniProt: Q86YC2

Pathways: DNA Damage Repair