DEC1 antibody (C-Term)

Catalog No. ABIN7454653

Product Details anti-DEC1 Antibody

Target: DEC1 (Deleted in Esophageal Cancer 1 (DEC1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-DEC1 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: between AA 350 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 to 1:2,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DEC1

Target: DEC1 (Deleted in Esophageal Cancer 1 (DEC1))

Alternative Name: DEC1 (DEC1 Products)

Synonyms: CTS9 antibody, DEC1 antibody, deleted in esophageal cancer 1 antibody, DEC1 antibody

Background: Background: DEC1 is a basic helix-loop-helix transcription factor that appears to play a role in cell differentiation, proliferation, apoptosis, and the circadian rhythm. DEC1 is able to promote chondrogenic and osteogenic differentiation in mesenchymal stem cells by activating transcription of bone-related genes. When it is overexpressed in cells it can suppress apoptosis by blocking caspase activation and inducing transcription of survivin. DEC1 has also been found to play a role mammalian in circadian rhythm as a suppressor of the CLOCK/BMAL1 promoter.

Gene ID: 8553

NCBI Accession: NP_003661

UniProt: O14503