PRPF31 antibody (AA 449-499)

Catalog No. ABIN7454569

Product Details anti-PRPF31 Antibody

Target: PRPF31 (Pre-mRNA Processing Factor 31 (PRPF31))

Binding Specificity: AA 449-499

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRPF31 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-PRPF31 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 449 and 499

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PRPF31

Target: PRPF31 (Pre-mRNA Processing Factor 31 (PRPF31))

Alternative Name: PRPF31 (PRPF31 Products)

Background: Background: Pre-mRNA-processing factor 31 (PRPF31) is involved in pre-mRNA splicing and is required for U4/U6.U5 tri-snRNP formation. Defects in the PRPF31 gene are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field [taken from the Universal Protein Resource (UniProt) Q8WWY3].

Gene ID: 26121

NCBI Accession: NP_056444

UniProt: Q8WWY3

Pathways: Ribonucleoprotein Complex Subunit Organization