PAGR1 antibody (AA 204-254)

Catalog No. ABIN7454425

Product Details anti-PAGR1 Antibody

Target: PAGR1 (PAXIP1 Associated Glutamate-Rich Protein 1 (PAGR1))

Binding Specificity: AA 204-254

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAGR1 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-PA1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 204 and 254

Isotype: IgG

Application Details

Application Notes:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-PA1 antibody A301-978A.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PAGR1

Target: PAGR1 (PAXIP1 Associated Glutamate-Rich Protein 1 (PAGR1))

Alternative Name: PA1 (PAGR1 Products)

Synonyms: C16orf53 antibody, C25H16orf53 antibody, PA1 antibody, 2900092E17Rik antibody, C77040 antibody, PAGR1 antibody, GAS antibody, Pa1 antibody, PAXIP1 associated glutamate rich protein 1 antibody, PAXIP1 associated glutamate rich protein 1A antibody, Paxip1-associated glutamate-rich protein 1 antibody, PAGR1 antibody, Pagr1a antibody, Pagr1 antibody

Background: Background: PA1 (PTIP-associated protein 1) was isolated as a protein that associates with PTIP (Pax transactivation domain-interacting protein), a nuclear protein involved in the DNA damage response and interacts with the Pax2 transactivation domain. Along with PTIP, PA1 has been found to be present in a MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase complex. PA1 also appears to be important to the DNA damage response and repair. This involvement in DNA damage signaling is reported to be independent of its MLL association. PA1 has also been identified as GAS (glutamate-rich coactivator interacting with SRC1/NCOA1). As an interactor of SRC1 (steroid receptor coactivator 1), PA1 functions as a transcription cofactor.

Gene ID: 79447

NCBI Accession: NP_078792

UniProt: Q9BTK6