UBR4 antibody (AA 5133-5183)

Catalog No. ABIN7453830

Product Details anti-UBR4 Antibody

Target: UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))

Binding Specificity: AA 5133-5183

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR4 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-p600 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat

Purification: Affinity Purified

Immunogen: between AA 5133 and 5183

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended. Use rabbit anti-p600 antibody A302-277A or A302-278A.

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for UBR4

Target: UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))

Alternative Name: p600 (UBR4 Products)

Synonyms: ZUBR1 antibody, RBAF600 antibody, p600 antibody, 1810009A16Rik antibody, A930005E13Rik antibody, D930005K06Rik antibody, Gm1032 antibody, Gm1666 antibody, N28143 antibody, Zubr1 antibody, mKIAA0462 antibody, Rbaf600 antibody, ubiquitin protein ligase E3 component n-recognin 4 antibody, E3 ubiquitin-protein ligase UBR4 antibody, UBR4 antibody, Ubr4 antibody, LOC100511934 antibody

Background: Background: p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) Q5T4S7].

Gene ID: 23352

NCBI Accession: NP_065816

UniProt: Q5T4S7