PELP1 antibody (AA 1000-1050)

Catalog No. ABIN7453550

Product Details anti-PELP1 Antibody

Target: PELP1 (Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1))

Binding Specificity: AA 1000-1050

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PELP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-PELP1/MNAR Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1000 and 1050

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PELP1

Target: PELP1 (Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1))

Alternative Name: PELP1/MNAR (PELP1 Products)

Synonyms: MNAR antibody, P160 antibody, RGD1306320 antibody, 4930563C04Rik antibody, proline, glutamate and leucine rich protein 1 antibody, proline, glutamate and leucine rich protein 1 L homeolog antibody, proline, glutamic acid and leucine rich protein 1 antibody, PELP1 antibody, Pelp1 antibody, pelp1.L antibody

Background: Background: PELP1/MNAR was identified as an SH2 domain interacting protein that interacts with Lck, c-Src, and other members of the Src kinase family. PELP1/MNAR appears to function as a general coregulator and interacts with multiple nuclear receptors and transcription factors. PELP1/MNAR has also been shown to participate in nongenomic signaling via an association with a multiprotein complex, the ""signalsome"" involving ERalpha, Src kinase, PI3K, SHC, and G-proteins. As a transcriptional coregulator and signaling protein, PELP/MNAR mediates a variety of cellular functions such as cell proliferation, apoptosis, differentiation, oncogenesis and metastasis.

Gene ID: 27043

UniProt: Q8IZL8