NPAT antibody (AA 1377-1427)

Catalog No. ABIN7453485

Product Details anti-NPAT Antibody

Target: NPAT (Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT))

Binding Specificity: AA 1377-1427

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPAT antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Purpose: Rabbit anti-NPAT Antibody, Affinity Purified

Predicted Reactivity: Mouse

Purification: Affinity Purified

Immunogen: between AA 1377 and 1427

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for NPAT

Target: NPAT (Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT))

Alternative Name: NPAT (NPAT Products)

Synonyms: NPAT-like antibody, im:6901964 antibody, DKFZp469B186 antibody, 6820401K01 antibody, AI427561 antibody, BB112559 antibody, E14 antibody, E14/NPAT antibody, p220 antibody, nuclear protein, co-activator of histone transcription antibody, nuclear protein, coactivator of histone transcription antibody, protein NPAT antibody, nuclear protein, ataxia-telangiectasia locus antibody, nuclear protein in the AT region antibody, nuclear protein, ataxia-telangiectasia locus S homeolog antibody, Npat antibody, NPAT antibody, LOC489420 antibody, npat antibody, LOC100286556 antibody, LOC100402032 antibody, LOC100480887 antibody, LOC100540521 antibody, LOC100561473 antibody, LOC100627195 antibody, npat.S antibody

Background: Background: NPAT (nuclear protein of the ataxia telangiectasia mutated locus) is required for progression through the G1 and S phases of the cell cycle and for S phase entry. It activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. NPAT also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q14207].

Gene ID: 4863

NCBI Accession: NP_002510

UniProt: Q14207