SMG1 antibody (AA 1625-1675)

Catalog No. ABIN7452857

Product Details anti-SMG1 Antibody

Target: SMG1 (pi-3-Kinase-Related Kinase SMG-1 (SMG1))

Binding Specificity: AA 1625-1675

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMG1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit anti-SMG1 Antibody, Affinity Purified

Predicted Reactivity: Mouse

Purification: Affinity Purified

Immunogen: between AA 1625 and 1675

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended. A300-394A is recommended.

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SMG1

Target: SMG1 (pi-3-Kinase-Related Kinase SMG-1 (SMG1))

Alternative Name: SMG1 (SMG1 Products)

Synonyms: 61E3.4 antibody, ATX antibody, LIP antibody, 2610207I05Rik antibody, 5430435M13Rik antibody, C130002K18Rik antibody, mKIAA0421 antibody, zgc:152973 antibody, SMG1, nonsense mediated mRNA decay associated PI3K related kinase antibody, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) antibody, SMG1 phosphatidylinositol 3-kinase-related kinase antibody, Serine/threonine-protein kinase smg-1 antibody, SMG1 antibody, Smg1 antibody, smg1 antibody, smg-1 antibody

Background: Background: SMG1 is a PIKK (phosphoinositide 3-kinase related kinases) protein kinase that plays a key role in RNA surveillance via nonsense-mediated mRNA decay (NMD). SMG1 phosphorylates Upf1, a factor that possesses RNA helicase activity and is also central to NMD. SMG1 and UPF-1 have been shown to exist in a complex with the translation termination release factors eRF3, and eRF1. This complex has been termed SURF and associates with the exon junction complex (EJC) to function in the recognition of premature termination codons in aberrant RNAs to trigger NMD.

Gene ID: 23049

UniProt: Q96Q15, Q96QV0

Pathways: Inositol Metabolic Process