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TBC1D23 antibody (AA 525-575)

TBC1D23 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7452842
  • Target See all TBC1D23 products
    TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
    Binding Specificity
    • 4
    • 1
    • 1
    • 1
    AA 525-575
    Reactivity
    • 9
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 9
    Rabbit
    Clonality
    • 9
    Polyclonal
    Conjugate
    • 6
    • 1
    • 1
    • 1
    This TBC1D23 antibody is un-conjugated
    Application
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Purpose
    Rabbit anti-TBC1D23 Antibody, Affinity Purified
    Predicted Reactivity
    Mouse,Zebrafish,X. laevis,Chicken,Orangutan
    Purification
    Affinity Purified
    Immunogen
    between AA 525 and 575
    Isotype
    IgG
  • Application Notes

    IP: 50-100 μL/mg lysate

    WB: 1:10,000 - 1:25,000

    Restrictions
    For Research Use only
  • Concentration
    1000 μg/mL
    Buffer
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Expiry Date
    12 months
  • Target
    TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
    Alternative Name
    TBC1D23 (TBC1D23 Products)
    Synonyms
    RGD1307925 antibody, NS4ATP1 antibody, 4930451A13Rik antibody, AU015720 antibody, AU043671 antibody, AU043778 antibody, D030022P07Rik antibody, W51689 antibody, zgc:63756 antibody, TBC1 domain family, member 23 antibody, TBC1 domain family member 23 antibody, Tbc1d23 antibody, TBC1D23 antibody, tbc1d23 antibody
    Background
    Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].
    Gene ID
    55773
    UniProt
    Q9NUY8
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