TBC1D23 antibody (AA 525-575)
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- Target See all TBC1D23 products
- TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
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Binding Specificity
- AA 525-575
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TBC1D23 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Purpose
- Rabbit anti-TBC1D23 Antibody, Affinity Purified
- Predicted Reactivity
- Mouse,Zebrafish,X. laevis,Chicken,Orangutan
- Purification
- Affinity Purified
- Immunogen
- between AA 525 and 575
- Isotype
- IgG
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- Application Notes
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IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
- Restrictions
- For Research Use only
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- Concentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Expiry Date
- 12 months
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- Target
- TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))
- Alternative Name
- TBC1D23 (TBC1D23 Products)
- Synonyms
- RGD1307925 antibody, NS4ATP1 antibody, 4930451A13Rik antibody, AU015720 antibody, AU043671 antibody, AU043778 antibody, D030022P07Rik antibody, W51689 antibody, zgc:63756 antibody, TBC1 domain family, member 23 antibody, TBC1 domain family member 23 antibody, Tbc1d23 antibody, TBC1D23 antibody, tbc1d23 antibody
- Background
- Background: TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) Q9NUY8].
- Gene ID
- 55773
- UniProt
- Q9NUY8
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