C17ORF85 antibody (AA 25-75)

Catalog No. ABIN7452805

Product Details anti-C17ORF85 Antibody

Target: C17ORF85 (Chromosome 17 Open Reading Frame 85 (C17ORF85))

Binding Specificity: AA 25-75

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C17ORF85 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-C17orf85 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 25 and 75

Isotype: IgG

Application Details

Application Notes:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for C17ORF85

Target: C17ORF85 (Chromosome 17 Open Reading Frame 85 (C17ORF85))

Alternative Name: C17orf85 (C17ORF85 Products)

Synonyms: ELG antibody, HSA277841 antibody, C130061O14Rik antibody, C78393 antibody, nuclear cap binding subunit 3 antibody, nuclear cap binding subunit 3 L homeolog antibody, NCBP3 antibody, Ncbp3 antibody, ncbp3.L antibody

Background: Background: C17orf85 (NCBP3) associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. C17orf85 (NCBP3) serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with C17orf85 (NCBP3) does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the C17orf85 (NCBP3) activity is critical to inhibit virus growth. [taken from the Universal Protein Resource (UniProt) Q53F19].

Gene ID: 55421

UniProt: Q53F19