SMCP antibody (AA 575-625)

Catalog No. ABIN7452707

Product Details anti-SMCP Antibody

Target: SMCP (Sperm Mitochondria Associated Cysteine Rich Protein (SMCP))

Binding Specificity: AA 575-625

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMCP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-MCSP Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 575 and 625

Isotype: IgG

Application Details

Application Notes:

IP: 5 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SMCP

Target: SMCP (Sperm Mitochondria Associated Cysteine Rich Protein (SMCP))

Alternative Name: MCSP (SMCP Products)

Synonyms: HSMCSGEN1 antibody, MCS antibody, MCSP antibody, Mcs antibody, Mcsp antibody, sperm mitochondria associated cysteine rich protein antibody, sperm mitochondria-associated cysteine-rich protein antibody, SMCP antibody, Smcp antibody

Background: Background: Melanoma chondroitin sulfate proteoglycan (MCSP) is a cell-surface antigen expressed early in melanoma progression. It has been found to be involved in the spreading, invasion, and migration of human melanoma. MCSP influences melanoma behavior via the activation of the Cdc42 GTPase and phosphorylation of p130Cas. MCSP also activates signaling cascades involving FAK and ERK1/ERK2. In addition to its expression in melanoma cells, MCSP is also found in breast carcinomas, gliomas, neuroblastomas, and acute leukemias. MCSP is being considered as a target antigen for cancer immunotherapy.

Gene ID: 1464

NCBI Accession: NP_001888

UniProt: Q6UVK1