PAPPA antibody (AA 1321-1460) (Biotin)

Catalog No. ABIN718933

Product Details anti-PAPPA Antibody (Biotin)

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Binding Specificity: AA 1321-1460

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAPPA antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PAPPA

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PAPPA

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Alternative Name: PAPPA (PAPPA Products)

Synonyms: 8430414N03Rik antibody, IGFBP-4ase antibody, PAG1 antibody, PAPP-A antibody, ASBABP2 antibody, DIPLA1 antibody, PAPA antibody, PAPPA1 antibody, Pappa antibody, pappalysin 1 antibody, pregnancy-associated plasma protein A antibody, PAPPA antibody, Pappa antibody, Pappa1 antibody

Background:

Synonyms: PAPA, DIPLA1, PAPP-A, PAPPA1, ASBABP2, IGFBP-4ase, Pappalysin-1, Insulin-like growth factor-dependent IGF-binding protein 4 protease, IGF-dependent IGFBP-4 protease, Pregnancy-associated plasma protein A, PAPPA

Background: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Gene ID: 5069

UniProt: Q13219