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TDP1 antibody (AA 75-125)

TDP1 Reactivity: Human IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7452451
  • Target See all TDP1 Antibodies
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    Binding Specificity
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 75-125
    Reactivity
    • 41
    • 15
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 34
    • 7
    • 1
    Rabbit
    Clonality
    • 37
    • 5
    Polyclonal
    Conjugate
    • 28
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    This TDP1 antibody is un-conjugated
    Application
    • 36
    • 22
    • 10
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunoprecipitation (IP)
    Purpose
    Rabbit anti-TDP1 Antibody, Affinity Purified
    Purification
    Affinity Purified
    Immunogen
    between AA 75 and 125
    Isotype
    IgG
    Top Product
    Discover our top product TDP1 Primary Antibody
  • Application Notes

    IP: 2 - 5 μg/mg lysate

    WB: Not recommended. Use rabbit anti-TDP1 antibody ABIN7453800.

    Restrictions
    For Research Use only
  • Concentration
    1000 μg/mL
    Buffer
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Expiry Date
    12 months
  • Target
    TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
    Alternative Name
    TDP1 (TDP1 Products)
    Synonyms
    2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, MLZ-501 antibody, SCAN1 antibody, tdp1 antibody, MGC83708 antibody, TDP1 antibody, F8M21.60 antibody, F8M21_60 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA Phosphodiesterase (Tdp1) antibody, tyrosyl-DNA phosphodiesterase 1 L homeolog antibody, tyrosyl-DNA phosphodiesterase-like protein antibody, TDP1 antibody, Tc00.1047053511191.10 antibody, Tdp1 antibody, tdp1.L antibody, tdp1 antibody, PTRG_11198 antibody, MCYG_02121 antibody, MGYG_03035 antibody
    Background
    Background: Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme that participates in the repair of DNA strand breaks associated with topoisomerase 1 (Top1) complexes. TDP1 catalyzes the removal of Top1 from DNA via the hydrolysis of the phosphodiester bond between the tyrosine residue of Top1 and the 3' phosphate of DNA. Removal of Top1 is then followed by DNA repair. TDP1 has been proposed to play more general roles in DNA damage repair independent of the Top1 complex. TDP1 has been shown to associate with DNA ligase IIIalpha, a component of the DNA single-stranded break repair (SSBR) machinery. It is also able to remove glycolate from 3'-phosphoglycolate termini of double-stranded breaks and a variety of other 3'- adducts. Defects in TDP1 are associated with spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1), a disease associated with peripheral axonal motor and sensory neuropathy and distal muscular atrophy.
    Gene ID
    55775
    NCBI Accession
    NP_001008744
    UniProt
    Q9NUW8
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