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BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-50) antibody

BABAM1 Reactivity: Human IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7452241
  • Target See all BRISC and BRCA1 A Complex Member 1 (BABAM1) Antibodies
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Binding Specificity
    • 10
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-50
    Reactivity
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 21
    • 4
    • 1
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    Un-conjugated
    Application
    • 24
    • 16
    • 13
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunoprecipitation (IP)
    Purpose
    Rabbit anti-MERIT40 Antibody, Affinity Purified
    Predicted Reactivity
    Orangutan
    Purification
    Affinity Purified
    Immunogen
    between AA 1 and 50
    Isotype
    IgG
    Top Product
    Discover our top product BABAM1 Primary Antibody
  • Application Notes

    IP: 2 - 5 μg/mg lysate

    WB: Not recommended. ABIN7452241 has not performed satisfactorily when used for WB of MERIT40 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of MERIT40.

    Restrictions
    For Research Use only
  • Concentration
    1000 μg/mL
    Buffer
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Expiry Date
    12 months
  • Target
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Alternative Name
    MERIT40 (BABAM1 Products)
    Synonyms
    merit40 antibody, nba1 antibody, zgc:100909 antibody, c19orf62 antibody, C19orf62 antibody, MERIT40 antibody, NBA1 antibody, C7H19orf62 antibody, 5430437P03Rik antibody, Merit40 antibody, BRISC and BRCA1 A complex member 1 antibody, BRISC and BRCA1 A complex member 1 L homeolog antibody, babam1 antibody, BABAM1 antibody, babam1.L antibody, Babam1 antibody
    Background
    Background: MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) Q9NWV8].
    Gene ID
    29086
    NCBI Accession
    NP_054892
    UniProt
    Q9NWV8
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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