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TOPBP1 antibody (C-Term)

TOPBP1 Reactivity: Human, Mouse WB, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7452107
  • Target See all TOPBP1 Antibodies
    TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
    Binding Specificity
    • 14
    • 12
    • 8
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 50
    • 13
    • 9
    Human, Mouse
    Host
    • 47
    • 3
    • 2
    Rabbit
    Clonality
    • 50
    • 2
    Polyclonal
    Conjugate
    • 25
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TOPBP1 antibody is un-conjugated
    Application
    • 28
    • 27
    • 15
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Purpose
    Rabbit anti-TopBP1 Antibody, Affinity Purified
    Purification
    Affinity Purified
    Immunogen
    between AA 1400 and C-term
    Isotype
    IgG
    Top Product
    Discover our top product TOPBP1 Primary Antibody
  • Application Notes

    IP: 2 - 5 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    Restrictions
    For Research Use only
  • Concentration
    1000 μg/mL
    Buffer
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Expiry Date
    12 months
  • Target
    TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))
    Alternative Name
    TopBP1 (TOPBP1 Products)
    Synonyms
    RGD1562949 antibody, TOPBP1 antibody, cut5 antibody, F2P24.3 antibody, F2P24_3 antibody, meiosis defective 1 antibody, TOP2BP1 antibody, 1110031N14Rik antibody, 2810429C13Rik antibody, AI256758 antibody, D430026L04Rik antibody, mKIAA0259 antibody, TopBP1-A antibody, TopBP1-B antibody, Xmus101 antibody, XtopBP antibody, mus101 antibody, top2bp1 antibody, DNA topoisomerase II binding protein 1 antibody, topoisomerase (DNA) II binding protein 1 antibody, dna topoisomerase ii binding protein 1 (IC) antibody, transcription coactivator antibody, DNA topoisomerase II binding protein 1 L homeolog antibody, Topbp1 antibody, topbp1 antibody, TOPBP1 antibody, MEI1 antibody, topbp1.L antibody
    Background
    Background: Topoisomerases regulate topological states of DNA. DNA topoisomerase II-binding protein 1 (TopBP1) is a protein that interacts with the C-terminal region of topoisomerase II beta (Topo II beta). TopBP1 function has been found to be important to various aspects of cellular growth control such as DNA replication, the DNA damage checkpoint, and cell survival. TopBP1 interacts with several proteins through its BRCA1 C-terminal (BRCT) motifs. TopBP1 interacts and inhibits E2F1 transcriptional activity through an Rb-independent mechanism that involves recruitment of the SWI/SNF chromatin-remodeling complex proteins Brg1 and Brm.
    Gene ID
    11073
    NCBI Accession
    NP_008958
    UniProt
    Q92547
    Pathways
    Chromatin Binding
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