PDE8B antibody (AA 835-885)

Catalog No. ABIN7451947

Product Details anti-PDE8B Antibody

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Binding Specificity: AA 835-885

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-PDE8B Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 835 and 885

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B (PDE8B Products)

Background: Background: Phosphodiesterase 8B is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. PDE8B, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in the PDE8B gene are a cause of autosomal dominant striatal degeneration (ADSD) [taken from NCBI Entrez Gene (Gene ID: 8622)].

Gene ID: 8622

NCBI Accession: NP_003710

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process