GEMIN5 antibody (AA 1360-1410)

Catalog No. ABIN7451794

Product Details anti-GEMIN5 Antibody

Target: GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))

Binding Specificity: AA 1360-1410

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEMIN5 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-Gemin5 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1360 and 1410

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for GEMIN5

Target: GEMIN5 (Gem (Nuclear Organelle) Associated Protein 5 (GEMIN5))

Alternative Name: Gemin5 (GEMIN5 Products)

Synonyms: GEMIN-5 antibody, AA407055 antibody, AA407208 antibody, AI451603 antibody, BB194447 antibody, C330013N08 antibody, gem nuclear organelle associated protein 5 antibody, gem (nuclear organelle) associated protein 5 antibody, GEMIN5 antibody, Gemin5 antibody

Background: Background: Gemin5 is a component of the SMN (survival of motor neurons) complex. The SMN complex is composed of the SMN protein and several Gemins (2-7) and is involved in the assembly of snRNPs in the cytoplasm and their transport to the nucleus. The SMN complex localizes to nuclear focal structures called gems or Gemini of coiled bodies. Gemin 5 has been shown to be responsible for recognizing and binding the snRNP code during snRNP biogenesis. Recent studies have shown that Gemin 5 is rarely detectable in SMN complexes associated with gems/Cajal bodies in the nucleus and may play a specific role in cytoplasmic SMN complexes. It has also been shown to function as a scaffold protein for ASK1-JNK1 signaling.

Gene ID: 25929

NCBI Accession: NP_056280

UniProt: Q8TEQ6

Pathways: Ribonucleoprotein Complex Subunit Organization