BRAP antibody (AA 560-592)

Catalog No. ABIN7451664

Product Details anti-BRAP Antibody

Target: BRAP (BRCA1 Associated Protein (BRAP))

Binding Specificity: AA 560-592

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRAP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-BRAP Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 560 and 592

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for BRAP

Target: BRAP (BRCA1 Associated Protein (BRAP))

Alternative Name: BRAP (BRAP Products)

Synonyms: imp antibody, MGC68778 antibody, zgc:92894 antibody, BRAP antibody, BRAP2 antibody, IMP antibody, RNF52 antibody, 3010002G07Rik antibody, BRCA1 associated protein S homeolog antibody, BRCA1 associated protein antibody, BRCA1-associated protein antibody, brca1-associated protein antibody, brap.S antibody, brap antibody, BRAP antibody, NAEGRDRAFT_81654 antibody, CC1G_00971 antibody, CpipJ_CPIJ003557 antibody, Tsp_05101 antibody, LOC100282389 antibody, Brap antibody

Background: Background: BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport [taken from the Universal Protein Resource (UniProt) Q7Z569].

Gene ID: 8315

NCBI Accession: NP_006759

UniProt: Q7Z569