ASXL2 antibody (AA 600-650)

Catalog No. ABIN7451647

Product Details anti-ASXL2 Antibody

Target: ASXL2 (Additional Sex Combs Like 2 (ASXL2))

Binding Specificity: AA 600-650

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASXL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-ASXL2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 600 and 650

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ASXL2

Target: ASXL2 (Additional Sex Combs Like 2 (ASXL2))

Alternative Name: ASXL2 (ASXL2 Products)

Synonyms: asxh2 antibody, ASXH2 antibody, 4930556B16Rik antibody, mKIAA1685 antibody, additional sex combs like 2, transcriptional regulator antibody, additional sex combs like 2 (Drosophila) antibody, Asxl2 antibody, ASXL2 antibody, asxl2 antibody

Background: Background: The gene that encodes Additional sex combs-like protein 2 (ASXL2) is a homolog of the drosophila additional sex combs (Asx) gene. Drosophila Asx is in a class of proteins known as ETP (enhancers of trithorax and polycomb). ETP proteins regulate polycomb-group (PcG) and trithorax-group (trxG) proteins which function to modify the methylation of histones and structure of chromatin. Mutations in ASXL1 are implicated in the development of myelodysplastic syndromes (MDS), a group of hematological diseases characterized by ineffective hematopoiesis and a predisposition to acute myeloid leukemia (AML).

Gene ID: 55252

NCBI Accession: NP_060733

UniProt: Q76L83

Pathways: Positive Regulation of fat Cell Differentiation