KIDINS220 antibody (AA 1400-1450)

Catalog No. ABIN7451642

Product Details anti-KIDINS220 Antibody

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Binding Specificity: AA 1400-1450

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIDINS220 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-ARMS Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1400 and 1450

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for KIDINS220

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Alternative Name: ARMS (KIDINS220 Products)

Synonyms: ARMS antibody, fj35h03 antibody, kidins220 antibody, zgc:63531 antibody, dZ119J18.2 antibody, wu:fj35h03 antibody, 3110039L19Rik antibody, AI194387 antibody, AI316525 antibody, C330002I19Rik antibody, mKIAA1250 antibody, kinase D interacting substrate 220 antibody, kinase D-interacting substrate 220 antibody, kinase D-interacting substrate 220b antibody, kinase D-interacting substrate 220kDa antibody, KIDINS220 antibody, Kidins220 antibody, kidins220b antibody

Background: Background: Ankyrin repeat-rich membrane-spanning protein (ARMS) is also known as Kinase D-interacting substrate of 220 kDa (KIDINS220). ARMS Promotes prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Arms may play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. ARMS may play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. ARMS has also been shown to modulate stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway [taken from the Universal Protein Resource (UniProt) Q9ULH0].

Gene ID: 57498

NCBI Accession: NP_065789

UniProt: Q9ULH0