RRP8 antibody (AA 406-456)

Catalog No. ABIN7451332

Product Details anti-RRP8 Antibody

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Binding Specificity: AA 406-456

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRP8 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Purpose: Rabbit anti-RRP8 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 406 and 456

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-RRP8 antibody ABIN7453202.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RRP8

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Alternative Name: RRP8 (RRP8 Products)

Synonyms: KIAA0409 antibody, 1500003O22Rik antibody, 2900001K19Rik antibody, AW538116 antibody, RGD1308302 antibody, ribosomal RNA processing 8 antibody, ribosomal RNA processing 8, methyltransferase, homolog (yeast) antibody, RRP8 antibody, Rrp8 antibody

Background: Background: Ribosomal RNA-processing protein (RRP8) is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown [taken from the Universal Protein Resource (UniProt) O43159].

Gene ID: 23378

NCBI Accession: NP_056139

UniProt: O43159