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MAML2 antibody (AA 250-300)

MAML2 Reactivity: Human IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7451271
  • Target See all MAML2 Antibodies
    MAML2 (Mastermind-Like 2 (MAML2))
    Binding Specificity
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 250-300
    Reactivity
    • 26
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human
    Host
    • 16
    • 11
    Rabbit
    Clonality
    • 16
    • 11
    Polyclonal
    Conjugate
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAML2 antibody is un-conjugated
    Application
    • 23
    • 12
    • 11
    • 9
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunoprecipitation (IP)
    Purpose
    Rabbit anti-MAML2 Antibody, Affinity Purified
    Purification
    Affinity Purified
    Immunogen
    between AA 250 and 300
    Isotype
    IgG
    Top Product
    Discover our top product MAML2 Primary Antibody
  • Application Notes

    IP: 2 - 10 μg/mg lysate

    WB: Not recommended. Use rabbit anti-MAML2 antibody A300-682A.

    Restrictions
    For Research Use only
  • Concentration
    1000 μg/mL
    Buffer
    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Expiry Date
    12 months
  • Target
    MAML2 (Mastermind-Like 2 (MAML2))
    Alternative Name
    MAML2 (MAML2 Products)
    Synonyms
    5930431H10 antibody, BC032967 antibody, MAM-3 antibody, MAM2 antibody, MAM3 antibody, MLL-MAML2 antibody, mastermind like 2 (Drosophila) antibody, mastermind-like transcriptional coactivator 2 antibody, mastermind like transcriptional coactivator 2 antibody, Maml2 antibody, MAML2 antibody
    Background
    Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.
    Gene ID
    84441
    UniProt
    Q8IZL2
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