LZTS2 antibody (C-Term)

Catalog No. ABIN7451099

Product Details anti-LZTS2 Antibody

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LZTS2 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Purpose: Rabbit anti-LZTS2 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Bovine

Purification: Affinity Purified

Immunogen: Between AA 660 and C-term

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. ABIN7451099 has not performed satisfactorily when used for WB of LZTS2 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of LZTS2.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for LZTS2

Target: LZTS2 (Leucine Zipper, Putative Tumor Suppressor 2 (LZTS2))

Alternative Name: LZTS2 (LZTS2 Products)

Synonyms: lapser1 antibody, MGC89253 antibody, si:dkey-250a11.1 antibody, LAPSER1 antibody, BC014695 antibody, mKIAA1813 antibody, Lapser1 antibody, leucine zipper, putative tumor suppressor 2 antibody, leucine zipper tumor suppressor 2 antibody, leucine zipper, putative tumor suppressor 2a antibody, leucine zipper, putative tumor suppressor 2 S homeolog antibody, lzts2 antibody, LZTS2 antibody, lzts2a antibody, Lzts2 antibody, lzts2.S antibody

Background: Background: leucine zipper, putative tumor suppressor 2 (LZTS2) is az negative regulator of katanin-mediated microtubule severing and release from the centrosome. It is required for central spindle formation and the completion of cytokinesis. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. It is a negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin  [taken from the Universal Protein Resource (UniProt) Q9BRK4].

Gene ID: 84445

UniProt: Q9BRK4