PHLPP2 antibody (C-Term)

Catalog No. ABIN7450565

Product Details anti-PHLPP2 Antibody

Target: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLPP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-PHLPPL Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1275 and C-term

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PHLPP2

Target: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Alternative Name: PHLPPL (PHLPP2 Products)

Synonyms: PHLPPL antibody, phlppl antibody, AI481772 antibody, C130044A18Rik antibody, Phlppl antibody, RGD1562857 antibody, PH domain and leucine rich repeat protein phosphatase 2 antibody, PH domain and leucine rich repeat protein phosphatase 2 S homeolog antibody, PHLPP2 antibody, phlpp2.S antibody, phlpp2 antibody, Phlpp2 antibody

Background: Background: PHLPPL (PH domain leucine-rich repeat-containing protein phosphatase-like) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPPL has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPPL is also known as PHLPPL2 and functions similarly to its relative, PHLPP1. Recent studies show that PHLPPL and PHLPP selectively terminate Akt-signaling by targeting specific Akt isoforms.

Gene ID: 23035

NCBI Accession: NP_055835

UniProt: Q6ZVD8

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway