PAN3 antibody (AA 175-225)

Catalog No. ABIN7450539

Product Details anti-PAN3 Antibody

Target: PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))

Binding Specificity: AA 175-225

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAN3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-PAN3 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 175 and 225

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PAN3

Target: PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))

Alternative Name: PAN3 (PAN3 Products)

Synonyms: 2700050F09Rik antibody, A430027N15Rik antibody, AU014670 antibody, pan3 antibody, zgc:171628 antibody, PAN3 poly(A) specific ribonuclease subunit antibody, PAN3 poly(A) specific ribonuclease subunit S homeolog antibody, PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) antibody, Pan3 antibody, PAN3 antibody, pan3.S antibody, pan3 antibody

Background: Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) Q58A45].

Gene ID: 255967

UniProt: Q58A45