LIN54 antibody (AA 1-50)

Catalog No. ABIN7450416

Product Details anti-LIN54 Antibody

Target: LIN54 (Lin-54 Homolog (LIN54))

Binding Specificity: AA 1-50

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN54 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-LIN54 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for LIN54

Target: LIN54 (Lin-54 Homolog (LIN54))

Alternative Name: LIN54 (LIN54 Products)

Synonyms: CXCDC1 antibody, JC8.6 antibody, MIP120 antibody, 4832414L08 antibody, AI461788 antibody, mKIAA2037 antibody, RGD1311361 antibody, lin-54 DREAM MuvB core complex component antibody, lin-54 homolog (C. elegans) antibody, LIN54 antibody, Lin54 antibody

Background: Background: LIN54 is a component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, LIN54 acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner [taken from the Universal Protein Resource (UniProt) Q6MZP7].

Gene ID: 132660

NCBI Accession: NP_919258

UniProt: Q6MZP7

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases