CDK13 antibody (AA 1125-1175)

Catalog No. ABIN7450096

Product Details anti-CDK13 Antibody

Target: CDK13 (Cyclin-Dependent Kinase 13 (CDK13))

Binding Specificity: AA 1125-1175

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK13 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-CDC2L5 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Bovine

Purification: Affinity Purified

Immunogen: between AA 1125 and 1175

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CDK13

Target: CDK13 (Cyclin-Dependent Kinase 13 (CDK13))

Alternative Name: CDC2L5 (CDK13 Products)

Synonyms: CDC2L5 antibody, cdc2l5 antibody, wu:fe16d10 antibody, wu:fi49c05 antibody, CDC2L antibody, CHED antibody, hCDK13 antibody, 2310015O17Rik antibody, Cdc2l5 antibody, cyclin dependent kinase 13 antibody, cyclin-dependent kinase 13 antibody, CDK13 antibody, cdk13 antibody, Cdk13 antibody

Background: Background: CDC2-like kinase 5 (CDC2L5) is a member of the cyclin-dependent serine/threonine protein kinase family that plays a central role in cell cycle control. The CDC2L5 cDNA was first identified as CHED (cholinesterase-related cell-division controller) and cloned serendipitously in a screen using a cholinesterase-specific oligonucleotide probe in search of a link between cholinergic signaling and hematopoietic cell division control. Recently, the understanding of the physiological function of CDC2L5 has become clearer. Due to its localization to speckles in the nucleoplasm and its interaction with the splicing protein, ASF/SF2-associated protein p32, it was suggested to play a role in mRNA processing. Further studies showed that overexpression of CDC2L5 altered mRNA splicing patterns, and that CDC2L5 associated with L-type cyclins known to be involved in alternative splicing. These results have led to the conclusion that CDC2L5 is part of a subfamily of cyclin dependent kinases that play a role in the regulation of alternative splicing.

Gene ID: 8621

NCBI Accession: NP_003709

UniProt: Q14004