Afadin antibody (AA 1475-1525)

Catalog No. ABIN7449949

Product Details anti-Afadin Antibody

Target: Afadin (MLLT4)

Binding Specificity: AA 1475-1525

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Afadin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-AF6 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1475 and 1525

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Afadin

Target: Afadin (MLLT4)

Alternative Name: AF6 (MLLT4 Products)

Synonyms: MLLT4 antibody, af-6 antibody, af6 antibody, si:ch211-278j12.1 antibody, AF6 antibody, RP3-431P23.3 antibody, 5033403D15Rik antibody, Af-6 antibody, Afadin antibody, Gm314 antibody, I-afadin antibody, S-afadin antibody, Af6 antibody, afadin, adherens junction formation factor antibody, afadin, adherens junction formation factor L homeolog antibody, afadin, adherens junction formation factor a antibody, afadin antibody, AFDN antibody, afdn.L antibody, afdna antibody, LOC589923 antibody, LOC100177180 antibody, afdn antibody, Afdn antibody

Background: Background: AF6 was identified as part of a fusion with MLL (mixed lineage leukemia) in a t(6,11) genetic translocation. AF6 is also known as afadin (a splicing variant of AF6 found at adherins junction). AF6/afadin is an actin filament binding protein that binds to nectin at cadherin-based cell-cell adherens junctions and regulates cell-cell adhesion by mediating Ras signaling.

Gene ID: 4301

UniProt: P55196

Pathways: Cell-Cell Junction Organization