Claspin antibody (AA 900-950)
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- Target See all Claspin (CLSPN) Antibodies
- Claspin (CLSPN)
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Binding Specificity
- AA 900-950
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Claspin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Purpose
- Rabbit anti-Claspin Antibody, Affinity Purified
- Purification
- Affinity Purified
- Immunogen
- between AA 900 and 950
- Isotype
- IgG
- Top Product
- Discover our top product CLSPN Primary Antibody
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- Application Notes
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IP: 2 - 10 μg/mg lysate
WB: 1:1,000 - 1:10,000
- Restrictions
- For Research Use only
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- Concentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Expiry Date
- 12 months
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- Target
- Claspin (CLSPN)
- Alternative Name
- Claspin (CLSPN Products)
- Synonyms
- CLSPN antibody, xClaspin antibody, B130025E01 antibody, C85083 antibody, E130314M08Rik antibody, claspin antibody, claspin S homeolog antibody, Clspn antibody, CLSPN antibody, clspn antibody, clspn.S antibody
- Background
- Background: Claspin is a checkpoint protein that interacts with and regulates checkpoint kinase 1 (Chk1) in response to replication stress. The interaction between claspin and Chk1 has been demonstrated to be required for ATR-dependent Chk1 activation. The interaction involves the phosphorylation of claspin that may be accomplished by Chk1 kinase activity. Claspin has been found to localize to chromatin in both the presence and absence of damaged DNA and to associate with PCNA, as an essential component of the DNA replication machinery. This association with the replication machinery may indicate a role for claspin in linking replication to DNA damage signaling and Chk1 activation.
- Gene ID
- 63967
- UniProt
- Q9HAW4
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