MHC Class II HLA-DP/DQ/DR antibody

Catalog No. ABIN7449429

Product Details anti-MHC Class II HLA-DP/DQ/DR Antibody

Target: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MHC Class II HLA-DP/DQ/DR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]

Immunogen: Cells from human tonsil

Clone: CR3-43

Isotype: IgG

Application Details

Application Notes:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MHC Class II HLA-DP/DQ/DR

Target: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Alternative Name: HLA-DR/DP/DQ (HLA-DP/DQ/DR Products)

Background: Background: In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ~70 % similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.

Gene ID: 3122

NCBI Accession: NP_061984

UniProt: P01903

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response