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Background
Background: T lymphoma invasion and metastasis-inducing protein 1 (TIAM1) is a guanine-nucleotide exchange factor (GEF) that positively regulates the Rac1-GTPase. Through Rac1, TIAM1 promotes cell migration and adhesion by modulating the actin cytoskeleton. TIAM1 was originally identified as a gene that induced invasion of lymphocytes.