UBR4 antibody (AA 5133-5183)
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- Target See all UBR4 Antibodies
- UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))
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Binding Specificity
- AA 5133-5183
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This UBR4 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Purpose
- Rabbit anti-p600 IHC Antibody, Affinity Purified
- Predicted Reactivity
- Mouse,Rat,Horse,Pig,Orangutan,Monkey,Gorilla,Chimpanzee,Little brown bat,Northern white-cheeked gibbon,White-tufted-ear marmoset
- Purification
- Affinity Purified
- Immunogen
- Between AA 5133 and 5183
- Isotype
- IgG
- Top Product
- Discover our top product UBR4 Primary Antibody
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- Application Notes
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IHC-IF: 1:50 - 1:500
IHC: 1:100 - 1:500
- Restrictions
- For Research Use only
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- Concentration
- 250 μg/mL
- Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Expiry Date
- 12 months
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- Target
- UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4))
- Alternative Name
- p600 (UBR4 Products)
- Synonyms
- ZUBR1 antibody, RBAF600 antibody, p600 antibody, 1810009A16Rik antibody, A930005E13Rik antibody, D930005K06Rik antibody, Gm1032 antibody, Gm1666 antibody, N28143 antibody, Zubr1 antibody, mKIAA0462 antibody, Rbaf600 antibody, ubiquitin protein ligase E3 component n-recognin 4 antibody, E3 ubiquitin-protein ligase UBR4 antibody, UBR4 antibody, Ubr4 antibody, LOC100511934 antibody
- Background
- Background: p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) Q5T4S7].
- Gene ID
- 23352
- NCBI Accession
- NP_065816
- UniProt
- Q5T4S7
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