MAML2 antibody (C-Term)

Catalog No. ABIN7448985

Product Details anti-MAML2 Antibody

Target: MAML2 (Mastermind-Like 2 (MAML2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Purpose: Rabbit anti-MAML2 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,Naked mole rat,Small-eared galago,Little brown bat,African elephant,Crab-eating macaque,White-tufted-ear marmoset,Ferret

Purification: Affinity Purified

Immunogen: Between AA 1100 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MAML2

Target: MAML2 (Mastermind-Like 2 (MAML2))

Alternative Name: MAML2 (MAML2 Products)

Synonyms: 5930431H10 antibody, BC032967 antibody, MAM-3 antibody, MAM2 antibody, MAM3 antibody, MLL-MAML2 antibody, mastermind like 2 (Drosophila) antibody, mastermind-like transcriptional coactivator 2 antibody, mastermind like transcriptional coactivator 2 antibody, Maml2 antibody, MAML2 antibody

Background: Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.

Gene ID: 84441

UniProt: Q8IZL2