RRAGA antibody (AA 544-594)

Catalog No. ABIN7448966

Product Details anti-RRAGA Antibody

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Binding Specificity: AA 544-594

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRAGA antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Purpose: Rabbit anti-FIP1 IHC Antibody, Affinity Purified

Predicted Reactivity: Bovine,Horse,Pig,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Northern white-cheeked gibbon,Tasmanian devil

Purification: Affinity Purified

Immunogen: Between AA 544 and 594

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RRAGA

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Alternative Name: FIP1 (RRAGA Products)

Synonyms: FIP-1 antibody, FIP1 antibody, RAGA antibody, 1300010C19Rik antibody, AI255374 antibody, Raga antibody, Ras related GTP binding A antibody, Ras-related GTP binding A antibody, RRAGA antibody, Rraga antibody

Background: Background: FIP1 was originally identified as Rhe (rearranged in hypereosinophilia) and part of a fusion protein encoded by a genetic rearrangement between the N-terminal region of FIP1 (Rhe) and the C-terminal region of the platelet-derived growth factor receptor alpha (PDGFRalpha). The fusion protein exhibits aberrant tyrosine kinase activity and is associated with hypereosinophilic syndrome (HES), a rare hematologic disorder characterized by an overproduction of eosinophils that results in organ damage. FIP1 was also identified as FIP1-like 1 in a database search for a human homolog of the yeast Fip1p (factor interacting with PAP), a subunit of the yeast 3'-end processing complex, CPF (cleavage and polyadenylation factor). Human FIP1 was similarly found to interact with PAP and CPSF160 as part of the human CPSF (cleavage and polyadenylation specificity factor) complex. In association with CPSF160, FIP1 is able to recognize U-rich elements on pre-mRNA and stimulate PAP activity.

Gene ID: 81608

NCBI Accession: NP_112179

UniProt: Q6UN15