MAPKAP1 antibody (C-Term)

Catalog No. ABIN7448795

Product Details anti-MAPKAP1 Antibody

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purpose: Rabbit anti-Sin1 IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,Chicken,Turkey,Sheep,Bovine,Dog,Horse,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Tasmanian devil,Crab-eating macaque,Zebra finch,Small-eared galago,Chinese hamster,Naked mole rat,Gray short-tailed opossum,Thirteen-lined ground squirrel,West Indian ocean coelacanth,Little brown bat,Duckbill platypus

Purification: Affinity Purified

Immunogen: Between AA 470 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MAPKAP1

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Alternative Name: Sin1 (MAPKAP1 Products)

Background: Background: Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.

Gene ID: 79109

NCBI Accession: NP_001006618

UniProt: Q9BPZ7

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events