DMBT1 antibody

Catalog No. ABIN7384267

Product Details anti-DMBT1 Antibody

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMBT1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Human Deleted in malignant brain tumors 1 protein

Isotype: IgG

Application Details

Application Notes: IHC 1:200-1:500

Restrictions: For Research Use only

Handling

Concentration: 0.71 mg/mL

Buffer: PBS with 0.05 % Proclin300, 50 % glycerol, pH 7.3.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DMBT1

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Alternative Name: DMBT1 (DMBT1 Products)

Synonyms: GP340 antibody, muclin antibody, CRP antibody, CRP-[a] antibody, CRP-[b] antibody, Crpd antibody, DBMT1 antibody, gp300 antibody, p80 antibody, DMBT1 antibody, gp340 antibody, deleted in malignant brain tumors 1 antibody, deleted in malignant brain tumors 1 protein antibody, gp340 antibody, deleted in malignant brain tumors 1 S homeolog antibody, DMBT1 antibody, Dmbt1 antibody, LOC100064515 antibody, dmbt1 antibody, ST201phi2-1p340 antibody, dmbt1.S antibody

Background: Apactin, CRP, Crpd, DBMT1, Deleted in malignant brain tumors 1 protein, DMBT1, DMBT1 prototype precursor, Ebnerin, FLJ61058, Glycoprotein 300, Glycoprotein 340, GP340, Gp340 variant protein, GP340, Hensin, MGC164738, Muclin, p80, Pancrin, SAG, Salivary agglutinin, Surfactant pulmonary associated D binding protein, Vomeroglandin,Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.

Gene ID: 1755

UniProt: Q9UGM3

Pathways: Activation of Innate immune Response