ZNF451 antibody

Catalog No. ABIN7384122

Product Details anti-ZNF451 Antibody

Target: ZNF451 (Zinc Finger Protein 451 (ZNF451))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF451 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human ZNF451 (NP_001026794.1).

Isotype: IgG

Application Details

Application Notes: WB 1:200-1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ZNF451

Target: ZNF451 (Zinc Finger Protein 451 (ZNF451))

Alternative Name: ZNF451 (ZNF451 Products)

Synonyms: COASTER antibody, dJ417I1.1 antibody, 4930515K21Rik antibody, 4933435G09Rik antibody, AI596398 antibody, Kiaa0576-hp antibody, Znf451 antibody, mKIAA1702 antibody, zinc finger protein 451 antibody, ZNF451 antibody, Zfp451 antibody

Background: ZNF451,COASTER,dJ417I1.1,E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 63 kDa/115 kDa/121 kDa

Gene ID: 26036

UniProt: Q9Y4E5