SARS-CoV-2 Spike S2 antibody

Catalog No. ABIN7383760

Product Details anti-SARS-CoV-2 Spike S2 Antibody

Target: SARS-CoV-2 Spike S2

Reactivity: SARS Coronavirus-2 (SARS-CoV-2)

Host: Human, Mouse

Clonality: Monoclonal

Conjugate: This SARS-CoV-2 Spike S2 antibody is un-conjugated

Application: ELISA

Specificity: SARS-COV-2 Spike S2 Monoclonal Antibody(2019-nCoV)

Purification: Antigen affinity purification

Immunogen: Recombinant 2019-nCoV S2 Protein (ECD, His Tag),PKSR030505

Clone: D001

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:5,000-1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 0.2 μm filtered solution in PBS

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SARS-CoV-2 Spike S2

Target: SARS-CoV-2 Spike S2

Abstract: SARS-CoV-2 Spike S2 Products

Synonyms: E2 antibody, Surface Glycoprotein antibody, S antibody

Target Type: Viral Protein

Background: Coronavirus s2,coronavirus spike,cov spike,ncov,ncov s2,ncov spike,novel coronavirus s2,novel coronavirus spike,s2,Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.